By C. Ateras. East Central University, Ada Oklahoma.
A period of time will to the size they were prior to pregnancy or after weight elapse before the swelling resolves; during this time 1 mg amaryl with visa diabetes insipidus test, a loss cheap 1mg amaryl visa diabetes type 2 test results. Approximately a decade ago purchase amaryl 1mg fast delivery blood glucose excursions, there was a great There are many common questions women have deal of negative publicity directed toward breast regarding breast augmentation buy amaryl 4 mg diabetic diet kidney disease. Although this can be of some time, studies have not found any association between assistance, the shape and size of the picture may not silicone breast implants or breast cancer or autoimmune have any correlation to hers. Still, the silicone implants are now used only who have women put trial sizes in their bra. Others sug- in trial studies and have been replaced with saline (salt) gest buying an inexpensive bra of the desired size and implants. This is a misconception breast augmentation is an in-depth consultation with a because only the volume will become larger and not board-certified plastic surgeon. For instance, a woman associated with any procedure and these should be who wears a 32 bra, will continue to wear a 32 bra. Many women also obtain a Another common question relates to the implants wealth of information from the Internet. Sometimes, there performed, there are various options for how and where is also a stipend offered to help pay for surgery that is it is performed. There is an obvious difference between the two sides Detecting breast cancer (screening) involves self- and the implant will have to be replaced. Some women in this group may be candidates for chemoprevention, a Suggested Resources newer treatment that involves taking a medication www. Women aged 40 and above should have an annual mammogra- phy and continue with breast self-exam. Breast Cancer Over 200,000 women are diag- Exciting new imaging techniques are being devel- nosed with breast cancer each year, and this number is oped to diagnose early breast cancers, at smaller sizes expected to increase significantly over the next decade than were previously detectable. In the future, early breast cancer treatment may time, and at least 40,000 will die of the disease each not actually involve surgery as we know it. Most women who get breast cancer will survive standard techniques of surgery are now dramatically the disease, and the number of women dying per year less invasive, so that most women with breast cancer is expected to decrease. Most women will be deciding between two actual cause of most breast cancers is not known. The goal of these procedures is early conserving surgery (lumpectomy or wide excision/radi- detection of breast cancer because early treatment can ation) or mastectomy with or without reconstruction. A minimally Breast cancer is not only the most common non- invasive technique that accurately evaluates the axillary skin cancer in women, but is also the second deadliest lymph nodes (sentinel node dissection) is part of either as well. Breast cancer is Once the surgical treatment is completed and the mostly a disease of older women. In younger age medical oncologist, understanding that the recommen- groups, breast cancer is uncommon and screening tests dation for chemotherapy is not based on the surgery may be less effective. Screening rec- breast cancer today are treated by a multidisciplinary ommendations are also different for patients with a team comprised of several specialties. This discussion is for women who daily in the diagnosis and treatment of breast cancer. Women should be encouraged that management of Much research in the last 40 years has been done early-detected breast cancer involves increasingly less on screening for breast cancer, but guidelines do not invasive approaches and will be addressed through the always agree on what type of screening method to use interaction of a team of dedicated specialists. Breast tissue Suggested Resources extends from the breastbone medially to the underarm CancerSource. Mammography Breast Enlargement see Breast has been shown to be effective in decreasing breast can- Augmentation cer mortality. Since mammography is known to be an effective screening tool, a clinical trial that excludes it would be unethical. Some of the indirect Breast Examination A breast examination is evidence comes from studies including the meta-analy- a simple means of detecting changes in breast tissue. From these trials we see that breast cancer mortality decreased by about 25% in women aged 5069 years and by 18% in women in their 40s. One of the studies reviewed by Barton 1999 was the Canadian National Breast Screening Study. Top figure shows the lateral portion of the breast conducted with early mammography techniques, but and bottom the medial portion of the breast. The com- ponents include palpation, examination pattern, and duration and inspection. The entire breast is palpated using the boundaries previously outlined in a vertical strip pattern or lawnmower pattern. Levels of pressure for palpation of breast tissue in a cross- sectional view of the right breast. The examiner should make three outer edge of a dime at a superficial, intermediate, and circles with the finger pads, increasing the level of pressure (superfi- deep pressure. Checking the armpit and area above the collarbone for enlarged a useful prognostic sign for cancer. However, sponta- lymph nodes is usually performed, but has not been clin- neous nipple discharge may need further evaluation. Expression of fluid from a nipple is not formed every 12 years for all women over age 40. Canadian National discuss individual screening recommendations with Breast Screening Study-2: 13-year results of a randomized trial in women aged 5059 years. There is some overlap with mammogra- National Alliance of Breast Cancer Organizations. This is a simple means for women Breast-Feeding Human breast milk is now to detect changes in their own breast tissue. It is per- widely acknowledged to be the most complete form of formed each month, usually within a week after men- nutrition for infants, with a range of physiological and struation, when the breast is least bumpy. Patients should ask Through the ages, humans have been dependent on it for their health care providers for help in learning the its sustenance and even contraceptive attributes. The proper technique includes look- supports the observation of benefits for infants growth, ing at the breast and systematically examining the breast immunity, and development, as well as reduced financial using the middle three fingers. Likewise, breast-feeding has been shown to improve of breast cancer is reduced by breast self-examination. Patients need to be aware that risk of premenopausal breast cancer, and reduced risk of the evidence for self-breast examination is unproven osteoporosis. Yet, in spite of these advantages, ambiva- and that it may increase their chances of having a lence surrounds the practice because of the myriad of benign breast biopsy. The American Academy of Family factors that influence a womans ability and decision to Physicians, the American College of Obstetricians and commit to breast-feeding. Gynecologists, and the American Cancer Society all recommend routine teaching of breast self-examination. A breast health assessment, including Suggested Reading a review of breast self-examination and nipple evaluation, is prudent. Does this patient physiology of lactation (milk production) is an essential have breast cancer? The screening clinical breast examination: complement to successful breast-feeding. Findings from 752 081 thus, when you are born, you already have breast tissue clinical breast examinations reported to a national screening pro- (as does your newborn). Journal of the National Cancer secretory glands undergo most of their maturation post- Institute, 92, 971. Effect of breast self-examination techniques on the risk of death from sidered mature once capable of producing milk, and fully breast cancer. The external dome is comprised first-time mother, father, or friend, understanding our of the nipple that is the exit point for all the milk ducts health beliefs is an integral component of making healthy (aka lactiferous ducts) and the pigmented areola that behavior choices. For example, many people nancy and lactation), lymph drainage ports, and hair fol- believe breast-feeding is intuitive because it is a nat- licles. The art of breast-feeding is a learned glandular (alveolar) tissue that produces milk; ducts that skill, irrespective of a womans education level.
Histone modications have in fact been associated with a number of diseases such as cancer and neurological disorders order amaryl 2 mg mastercard diabetes symptoms high blood pressure. Collectively 1 mg amaryl sale diabetes diet nz, epigenetic processes are now generally accepted to play a key role in human diseases amaryl 1mg generic blood glucose 50. As the knowledge of epigenetic mechanisms in human diseases expands discount 2mg amaryl visa diabetes insipidus group, it is expected that approaches to disease prevention and therapy using epigenetic interventions will also continue to develop and may eventually become mainstays in disease management. Recent advances in epigenetic-based methods have served as major driving forces in the fascinating and ever-expanding epigenetic phenomena that have been revealed especially over the past decade. Combinations of epigenetic technologies are also emerging that show promise in leading to new advances in understanding the epigenetics of disease. Epigenome refer- ence maps will likely have an impact on our understanding of many different diseases and may lead the way to breakthroughs in the diagnosis, prevention and therapy of human cancers. Epigenetic therapy for cancer is perhaps one of the most exciting and rapidly developing areas of epigenetics. The development of drug-based inhibitors of these epigenetic-modifying enzymes could be further improved through drug combinations or even natural plant-based products, many of which have been found to harbor properties that can mimic the often more toxic and perhaps less bioavailable epigenetic drugs that are currently in use. At this point, however, the number of neurodevelopmental disorders that have been associated with epigenetic aberrations is not very extensive. In fact, many neurodevelopmental disorders are due to partial loss-of-function mutations or are X-chromosomal mosaics with recessive X-linked mutations. Neurodegenerative diseases such as Alzheimers disease have been increasingly associated with alternations in epigenetic processes. These factors may begin early in life and manifest as late-onset forms of Alzheimers disease. Epigenetic processes are central to aging and are also an important mediator between the environment and disease and it is thought that these factors may be important in the development and progression of numerous autoimmune diseases. However, both epigenetic and genetic factors are often important in human imprinting disorders and the development of epigenetic therapy approaches in this particular area represents a considerable challenge. Advances are being made in understanding the epigenetic basis of human imprinting disorders which may provide breakthroughs in treating these tragic diseases. It is likely that increased identication of obesity biomarkers and their associated epigenetic factors may lead to new advances in controlling the extant epidemic in childhood obesity in many developed countries. However, multisystem studies are currently needed to further substantiate this concept and additional studies on the prediction and prevention of type 2 diabetes are sorely needed. Additionally, this transgenerational component may allow for the transmittance of epigenetic changes to future generations beyond the offspring leading to allergic disorders. Novel early interventions into epigenetic-modifying factors such as maternal diet may contribute to an eventual decline in allergy-based disorders. Future efforts are now being directed toward modiers of other epigenetic processes in allergic disorders such as histone phosphorylation and ubiquitination. The consequences of these epigenome-modifying infections are not limited to neoplasia. There are, in fact, many other diseases that have an epigenetic basis induced by infectious agents such as diseases of the oral cavity. Knowledge accumulated regarding epigenetic invaders of the genome and their pathological consequences will undoubtedly lead to the development of more sophis- ticated and novel approaches to controlling and treating epigenetic-based infectious diseases. These ndings may have important epigenetic therapeutic implications for endometrial cancer and could also have potential for the prevention, diagnosis and risk assessment of endometrial cancer. Chromatin modications and dynamics appear to have an important role in conservation of pluripotency and the differentiation of embryonic stem cells which are central factors in stem cell-based therapeutics. Understanding the basic epigenetic changes central to these processes may have considerable potential in the treatment of human epigenetic diseases. Although aging is not considered a disease in and of itself, it is perhaps the most frequent contributor to human disease. Therefore, delaying the epigenetic aberrations associated with aging through epigenetic intervention and treating epigenetic-based age-associated diseases could have a tremendous impact on the role of epigenetics in human disease. The role of nutrition, hormones and metabolic environment early in life can have effects throughout life, inuence epigenetic pathways and markers and manifest in the form of aging and age-related diseases. Consid- erable interest is now focused on the impact of early life epigenetic impacts and the outcome of these effects on the myriad of age-associated diseases which comprise much of the pathology that forms the basis of human disease. These diseases, that can be loosely grouped under the heading of epigenetic diseases, are vast and the list of diseases that t into this description is rapidly growing. A common theme of many epigenetic-based human diseases is the role of the environment. Exciting advances are rapidly developing that are contributing signicantly toward the management of human diseases through epigenetic intervention. It is anticipated that epigenetic-based preventive and therapeutic strategies will continue to develop at a rapid pace and may assume a role at the forefront of medicine in the not too distant future. The Drosophila Fab-7 chromosomal element conveys epigenetic inheritance during mitosis and meiosis. Much of our increased understanding is the result of technological breakthroughs that have made it feasible to undertake large-scale epigenomic studies. In turn, we have a growing understanding of the consequences of aberrant patterns of epigenetic marks and of mutations in the epigenetic machinery in the etiology of disease. However, there are several aspects of the methods used to analyze epigenetic variation associ- ated with disease that present potential problems. This depends to some extent on the nature of the disease, and can inuence the analytical methods that are employed. Second, different diseases may require analysis of either regional or genome-wide epigenetic variation, with the choice depending on the predicted variation in the specic disease. The continuing increase in the number of epigenetic diseases means that the list of methods that are practical for the different diseases is also increasing. Therefore, use of strategies that can differentiate the role, or otherwise, of 8 epigenetic variation in the causality of a disease is fundamental. Although the new technologies have provided considerable insights into epigenetic aspects of disease, there is still considerably more work that needs to be carried out. The availability of detailed epigenetic maps will be of enormous value to basic and applied research and will enable pharmacological research to focus on the most promising epigenetic targets. This chapter summarizes some of the contemporary methods used to study epigenetics and highlights new methods and strategies that have considerable potential for future epigenetic and epigenomic studies. The use of restriction enzymes that are sensitive to CpG methylation within their cleavage recognition sites  is a relatively low-resolution method, but it can be useful when combined with genomic microarrays [7,8]. This approach is therefore generally regarded as the gold-standard technology for detection of 5-methyl cytosine as it enables mapping of methylated sites at single-base-pair resolution . However, the modied nucleoside 5-methyl cytosine is immune to transformation and, therefore, any cytosines that remain following bisulte treatment must have been methylated. This method is currently one of the most popular approaches to methylation analysis and yields reliable, high-quality data [9,10]. The drawback to the method is that it is labor-intensive and is not suitable for screening large numbers of samples. The various advantages and disadvantages of this approach have been reviewed previously [11e13]. Recent high-throughput studies have used protein afnity to enrich for methylated sequences and then exploited these sequences as probes in genomic microarrays. This protocol can be carried using multiplex reactions, thus enabling the simultaneous quantication of multiple CpG sites in each assay. Thus, while very sensitive, this assay may be more suited to laboratory diagnosis.
Apply a soft collar as soon as the skin is (2) allow you to separate the scar more easily purchase amaryl 2mg free shipping blood glucose monitor precision xtra, soundly healed cheap 2mg amaryl visa diabetes type 2 knowledge questionnaire, and leave it there for at least 6months cheap 1mg amaryl fast delivery diabetes symptoms glucose. Try to restore full abduction and elevation in a single If there are flexion contractures of the fingers discount amaryl 2 mg mastercard gestational diabetes test jelly beans, incise operation. If there is a broad contracture, incise the scar as them transversely maximally taking care not to damage above, and abduct the arm. Apply a large medium the digital nerves & arteries, and fill the gap with a full thickness split-skin graft to the bare areas, and secure it thickness, or a thick split-skin graft sutured into place. Cover this with plenty of dry For a child, splint the fingers in extension for 3months, wool, and bandage this (preferably with crepe bandages) or the contracture will recur. To help the cast stay in place, to include the whole arm as well as the axilla and chest. Examine the cast daily at first, and later weekly, to make sure it has not slipped. In a small child, a large ball of cotton wool bandaged into For an adult, do not immobilize the extended fingers for the axilla may hold the arm in the right position. Follow the general method, as described above, taking (1) Do not injure the axillary vessels or nerves. If there is an ulcer within a scar, think of squamous If you have found the right fatty plane, this should free up carcinoma: excise it with adequate margins and send it for the scar tissue. You are operating A Z-plasty is a useful way of releasing a contracture, for a flexion contracture so lack of flexion will not be a if it is narrow enough. If the contracture is mild, a dynamic splint may cure it, Make a Z-plasty by excising the scar and then cutting or at least partially correct the deformity, so that operation 2 flaps in the form of isosceles triangles which share one will be easier. When you extend the limb, the triangular flaps will change their positions If the wrist is hyperextended, divide the scar spontaneously. Initially, the 2 triangles together form a transversely, and apply a medium thickness split skin parallelogram, with its shorter diagonal in the line of the graft: beware of the median nerve and ulnar nerve & contracture, and its longer diagonal transversely across it artery! Use a pre-cut contracture diagonal is the same length as the transverse 60 pattern. Unfortunately, as most burns usually cause scarring in all directions, there may be no lax tissue available, making a Z-plasty impossible. If there is no transverse slack tissue to start with, a Z-plasty will not work on its own, but it still may be helpful combined with excision of scar and skin-grafting. This is necessary if the available lax tissue is not available at one point, but is spread out along the length of the scar. D, final result: the contracture diagonal has You have 2 ways of choosing the direction of the Zs. E,F, single Z showing how the lateral tension is either side of the central limb, in both of the possible ways. R, the flaps in place: note the special suture (2) avoid scarring across the base, at the apices. If you are experienced, you can avoid the trap-door appearance of curved scars by making multiple Z-plasties. Recurrent infection A,B, combining Z-plasties and skin grafting; make the Z-plasty with makes it adhere to the surrounding tissue, and become transverse incisions at each end of it. This will release the ends of the contracture maximally, without increasing its length: resolved. F,G, total excision of a scar with a split skin graft sewn in (3);Its contents can escape, and become hard and form a place. Do not use an elliptical incision, which may later be difficult to close without tension. Push the points of fine curved scissors between the cyst and the tissue round it, and then open them, so as to define a plane for dissection. Repeat this all round the cyst until it is free, then try to remove it intact with a snip of the scissors. Close the skin, leaving a small Penrose drain (4-14B) in place unless the cavity is completely dry. If the cyst is infected, incise and drain it but make no attempt to excise it till the infection has settled. If the cyst ruptures, try to remove all of its lining by operating gently with fine instruments; if you leave some behind, the cyst is likely to re-form. If there is any doubt about the diagnosis, take a If the cyst does not have sebaceous material but hair, piece for histology. You find these at the lines of skin fusion in the embryo, namely in the midline or, B. If the cyst turns out to be a fatty lump, it is a lipoma: excise it anyway, by shelling it out. An antibiotic is only needed rarely or infective, however, and may have different treatments: if there are signs of spreading infection. Prognosis is excellent if you treat lesions early, whether by surgery or radiotherapy. If you cannot do this, try hard to get help to make an adequate excision because otherwise it will recur and spread extensively. It will not spread to the regional lymph nodes, so there is no need to excise these. For very small lesions, radiotherapy offers no advantage over surgery, because the diagnosis has to be confirmed by biopsy anyway; for middle-sized or large lesions it is of some cosmetic value. A, this albino has already had several squamous skin (including particularly albinos) exposed to the sun. One has eroded the skull; it was successfully excised, They are rare in dark skins, except as a complication of and the dura grafted, leaving a large depression. D, radiograph of the same xeroderma pigmentosum (autosomal recessive sensitivity lesion, showing bone destruction and sclerosis. Unfortunately, albinos from disadvantaged families often face serious discrimination. A translucent area in the bone under the Try to excise a squamous carcinoma with any malignant ulcer shows that bone is being infiltrated. Uvastat, for example muscle, excise any deep fascia and apply a are very expensive; you can use zinc oxide on the lips as split skin graft. If bone is exposed, chisel away the cortex until you reach a bleeding surface, wait 7-14days for granulations to form, 34. Occasionally, you can close the defect with either a rotation, a transposition or In a black patient, malignant melanomas arise only from a myocutaneous flap. In a white patient, a melanoma can arise first joint proximal to the lesion instead. In all skin colours, malignant melanomas only occur If the regional lymph nodes are not hard or matted after puberty; most are pigmented, but a few are together, leave them. They may occur at the junction of block dissection prophylactically, because there is a 10% depigmented and pigmented skin in severe cases of chance that lymphoedema (34. If they do not respond, biopsy one, and make a (2) to the regional lymph nodes; deposits may also grow in careful follow-up. If you think that the nodes are involved clinically but Treatment is by wide surgical excision; there is no are not fixed to deeper structures, or there is an effective radiotherapy or chemotherapy. Amputation may advanced ulcer-cancer (most commonly in the groin), be necessary to obtain clearance. The patient must report any new deeply and lightly pigmented areas on the hands and feet. Advise the use of the fruit of (2),A deeply pigmented lesion on the sole of the foot, the sausage tree (Kigelia Africana): soften the skin of the >2cm in diameter, whether or not it is ulcerated.
This results in short peptide which is rapidly degraded leading to the absence of - o globin chains purchase amaryl 1mg on line diabetes iddm definition. Deletions & insertions - can occur within coding sequences or within noncoding sequences amaryl 2mg sale ketosis-prone diabetes mellitus type 2. This leads to altered amino acid sequence & usually premature termination of the peptide chain because of the occurrence of a termination codon in the altered reading frame buy generic amaryl 2 mg on-line blood sugar range. Deletion or insertion of three or a multiple of three base pairs within coding sequences does not cause frameshift mutation 1mg amaryl mastercard diabetes in dogs cost uk, instead it results in abnormal protein missing one or more amino acid. Expansion of repeat sequences (trinucleotide repeat mutations) - show expansion of a sequence of 3 nucleotides. Trinucleotide repeat mutation is when there is expansion of these normally repeated sequences to more than 100 repeats. Summary:- - Mutations can interfere with normal protein synthesis at various levels:- 1. Promoter/enhancer mutations No transcription/ increased transcription No protein/increased protein. Missense mutation Abnormal protein with a different amino acid A protein altered with function or loss of function 3. Nonsense mutation Affects translation Truncated protein Rapidly degraded protein Absence of the protein. These proteins include enzymes & structural components responsible for all the developmental & metabolic processes of an organism. Mutation Abnormal protein/No protein/ Increased protein Abnormal metabolic processes Tissue injury Genetic diseases. Categories of genetic diseases Genetic diseases generally fall into one of the following 4 categories: a. X-linked recessive inheritance The mode of inheritance for a given phenotypic trait/disease is determined by pedigree analysis in which all affected & unaffected individuals in the family are recorded in a pedigree using standard symbols & indicating the sex, the generation, & biologic relationship among the family members. In all mendelian disorders, the distribution of the parental alleles to their offspring depends on the combination of the alleles present in the parents. Autosomal dominant disorders - will be discussed under the following 4 headings:- a. Clinical examples - Dominant implies that the disease allele needs to be present only in a single copy (as in the heterozygote) to result in the phenotype. In a typical dominant pedigree, there can be many affected family members in each generation. Except for new mutation, every affected child will have an affected parent Some patients do not have affected parents because the disease in such cases is due to new mutations in the sperm/ovum from which the patients were derived. In the mating of an affected heterozygote to a normal homozygote (the usual situation), each child has a 50% chance to inherit the abnormal allele & be affected & a 50 % chance inherit the normal allele. The 2 sexes are affected in equal numbers (because the defective gene resides on one of the 22 autosomes (i. The exceptions to this rule are the sex-limited disorders such as breast & ovarian cancers in females & familial male precocious puberty in boys. This figure shows the pedigree for a normal female parent & an affected male parent & their four children. Vertical distribution of the condition through successive generations occurs when the trait does not impair reproductive capacity. Additional features of autosomal dominant disorders Each of the following may alter the idealized dominant pedigree (& they should be considered to provide the most accurate counselling):- i. New mutations are more often seen with diseases that are so severe that people who are affected by them are less likely to reproduce than normal. For example, the majority of cases of achondroplasia are the results of new mutations. Penetrance is the probability of expressing the phenotype given a defined genotype. Penetrance is expressed as the percentage of individuals who have the mutant allele & are actually phenotypically affected. For example, 25% penetrance indicates that 25% of those who have the gene 106 express the trait. Reduced (incomplete) penetrance is when the frequency of expression of a genotype is < 100%. Nonpenetrance is the situation in which the mutant allele is inherited but not expressed. Variable expressivity is the ability of the same genetic mutation to cause a phenotypic spectrum. It is when the trait is seen in all individuals carrying the mutant gene but is expressed differently among individuals. For example, some patients with neurofibromatosis type 1 (which is an autosomal dominant disorder) have only brownish spots (caf au lait spots) on their skin whereas other patients with the same disease have multiple skin tumors & skeletal deformities. Variable expressivity most likely results from the effects of other genes or environmental factors that modify the phenotypic expression of the mutant allele. For example, individuals with familial hypercholesterolemia who take cholesterol-rich diet have a higher risk of manifesting with atherosclerosis than those individuals with hypercholesterolemia & who take low cholesterol diet. Hence, the variable expressivity in this case is brought about by the influence of an environmental factor (i. In general, variable expressivity & reduced penetrance can modify the clinical picture of autosomal dominant disorders. Pathogenesis of autosomal dominant disorders Autosomal dominant disorders are caused by 2 types of mutations: 1. Loss of function mutations cause autosomal dominant disorders when they result in inactive or decreased amount of regulatory proteins (e. A 50% reduction in the levels of such nonenzyme proteins results in an abnormal phenotype (i. This can sometimes be explained by the dominant negative effect of the mutant allele (i. Clinical examples of autosomal dominant disorders: o Marfan syndrome* o Some variants of Ehlers Danlos syndrome o Osteogenesis imperfecta o Achondroplasia o Huntington disease o Neurofibromatosis* o Tuberous sclerosis o Myotonic dystrophy o Familial hypercholesterolemia* o Hereditary spherocytosis o Familial polyposis coli o Polycystic kidney disease * Only these are briefly described here. Marfan syndrome - is a defect of connective tissue characterized by faulty scaffolding. Microfibrils are normally abundant in the aorta, ligaments, & ciliary zonules of the lens where they support the lens. Hence, Marfan syndrome (in which there is deficiency of normal fibrillin & microfibrils) mainly involves these tissues. Patients are tall & thin with abnormally long legs & arms, spider like fingers (arachnodactyly), hyperextensible joints. Mitral valve prolapse due to loss of connective tissue support in the mitral valve leaflets. Dilatation of the ascending aorta due to cystic medionecrosis (lack of medial support). Dilatation of the aortic valve ring & the root of the aorta Aortic regurgitation. This knowledge of the pathogenesis of familial hypercholesterolemia has led to a logical discovery of its treatment. Familial neoplasms have neoplasm-causing mutations ransmitted through the germ line.