By Y. Joey. Elizabeth City State University.
However buy xalatan 2.5 ml otc symptoms jaundice, you now have the ability to 178 Dialogue: A Friendly Chat with Your Inner Child • 179 bring your adult consciousness to the child’s belief system 2.5 ml xalatan fast delivery symptoms leukemia. You now have the skills to examine whether that belief system is true or not and reflect this back to your inner child discount xalatan 2.5 ml line medications 230. You can use the following questions to begin a targeted dialogue that will question whether beliefs that you have held for a lifetime are true purchase 2.5 ml xalatan otc medications you cannot eat grapefruit with, realistic and ultimately valuable to you or not. To explore whether these core beliefs are true, you began by asking some targeted questions about what the beliefs were and what they meant. Now you will begin to question whether these beliefs are really true using your inner child’s own choice of words. For example, when Larry’s inner child was saying that buying the suit was “terrible”, Larry asked, “Is it terrible? The next question to ask your inner child, after addressing how bad the situation, action or occurrence actually is, is simply, “Are you safe? Larry asked his inner child: Is she here right now to punish you, not talk to you or be mean to you? Examining the validity of the belief that the inner child is not safe, loveable or worthy is the most difficult process. The child only feels loved based on how well it’s following the belief system of the caregiver in any given moment. Take a look at how Larry handled examining the truth behind his inner child’s beliefs. As the child sees that the beliefs it holds are not valid, not real, there can be some loosening of these strongly held beliefs. The child Dialogue: A Friendly Chat with Your Inner Child • 181 may be able to see, with more clarity, what’s really happening in a stressful situation. This clarity will ultimately make you less reactive and less stressed, as you continue with the practice of inner-child dialoguing. It’s dependent on caregivers and doesn’t feel that it’s capable of dealing with any real or perceived problems that may arise. However, the child still has a sense of justice and injustice, of what’s right or wrong. So far, you have begun an inner-child dialogue, most likely during a stressful time. You have listened to the child and have asked questions to try to discover some of the child’s inner, core beliefs. You’ve also begun to connect how these beliefs are affecting your actions as an adult. You’ve helped your inner child begin to understand the meaning behind some components of its belief system and you’ve uncovered some specific beliefs related to your current stressful situation, such as “spending money is bad”. Finally, you’ve challenged this belief by asking the inner child, “Is the situation really that bad? Of course, if Larry could not really afford the suit he could return it, sell it or find some way to make extra money to help pay for it. When you are focused on finding a possible solution to a problem or situation, your inner child can see that problems are not so overwhelming. There’s always some kind of a solution to whatever happens even if it’s not ideal. Inner-Child Dialogues in Action I hope you will take some time to have a conversation with your inner child the next time you’re stressed. My personal approach to inner-child dialogues, as well as the suggestions that I have given you for what questions to ask your inner child, will get you started. The underlying process remains the same in that, through inner-child dialogue, you are trying to identify the belief system, have the child clearly define what the belief system means and then examine the truth of it. The core belief system really is the controlling force in your behavior and it’s amazing how it impacts your day-to-day activities. Let’s look at how Larry’s core belief system influenced his life: • When someone was driving too slowly in front of him, Larry became upset. In his mind Larry had placed himself in the car that the other person was driving and became anxious because the other person was not driving the way that Larry felt was Dialogue: A Friendly Chat with Your Inner Child • 183 the right way to drive. This made Larry uncomfortable as it triggered a memory of his childhood experiences. His words “I hate him” were really a reflection of the words he used as a defenseless child who would silently say, “I hate you” to his domineering mother. On the surface level, Larry was upset with his colleague over the fact that he was yelling and not treating Larry respectfully. However, at a deeper more significant level, it brought up childhood memories of when his mother used to yell at him. She grew up in a family where her father was an alcoholic and could be verbally and physically abusive to the family. She didn’t know, when she was coming home from school, whether her father was going to be nice or abusive. When she would ask her mother why her father was being mean to her, her mother would say, “Your father’s not mean. By the time I met Mika, she had a long history of abdominal pain, nausea and fatigue. As she continued to push her feelings down, they leaked out through her physical pores. Anytime she was in a situation where she, even remotely, perceived that someone was upset with her, she would feel anxious. Let’s look at Mika, in this situation, as another example of how an inner-child dialogue can be rewarding. You’ll see how to put it all together using the process and questions that we’ve covered so far. In response to her boss’s request for a different file, Mika’s inner voice became active. She noticed that she was repeating certain negative comments and questions to herself and this became her cue to initiate an inner-child dialogue to reduce her stress levels. Dialogue: A Friendly Chat with Your Inner Child • 185 Mika’s inner voice was saying: This is terrible. What came out in the dialogue was that the surface situation of not bringing the right papers to her boss, and the fear of not doing a good job and being fired, was not the real reason for Mika’s intense stress-reaction. It was the childhood memory of her father’s anger that the situation triggered that was the real source of her stress, fear and anger. This was a very valuable discovery for her that a quick dialogue brought to light. Mika has the opportunity to comfort her inner child and reassure it that her experience with her boss is not the same as what she endured with her father. She also has a chance to examine the validity of her belief system to reduce the likelihood of future over-reactions. Mika’s history of abuse is a very powerful example of the trauma the inner child may have experienced. However, an effective means of loosening the grip of this unconscious force is to examine whether the child’s belief system is valid, reasonable, or true. Here is another sample conversation to show you how inner-child dialogue can be developed to get at the root of a stress-reaction. To question the truth of the inner child’s beliefs, Mika began with some questions regarding the feelings of the child in relation to love and self-worth. Mika asked: It seems that to be loveable and worthy you have to do everything that your father wants. The voice answered: One time I broke a glass and grandma said it was ok, nothing to be upset about. Mika commented: So it seems that you can be loved even if you’re not perfect, even if you don’t do everything that your dad wants.
Cassette integration or excision is effected by an integrase purchase xalatan 2.5 ml on-line medicine queen mary, expressed from a gene int also located on the integron 2.5 ml xalatan otc symptoms parkinsons disease. The integrase catalyzes a site-speciﬁc recombination cheap xalatan 2.5 ml mastercard medications for gout, which includes recognition of the 59be of the cassette by the integrase generic 2.5 ml xalatan symptoms leukemia, which by recombination integrates it at the speciﬁc attI site located at the upstream end of the int gene. The 59be end of the integrated cassette forms a new speciﬁc recombination site, attC, which is recognized by the integrase, particularly at the cutting out of cassettes. The integrase gene int is expressed from right to left, while the resistance genes (in this case, Tp for trimethoprim resistance via drug-resistant dihydrofolate reductase, and Oxa for oxacillin resistance via oxacillin-degrading betalactamase) are expressed from left to right and from the promoter P located in the upstream part of the int gene. Further cassettes can be inserted at the attI site, giving the integron the ability to form an assortment of integron-borne combinations of antibiotic resistance genes. A single integron has been observed to carry eight different antibiotic resistance cassettes. This promoter is responsible for the transcription of the structural genes in all the cassettes situated downstream of the attIsite. The integron is thus a very efﬁcient vehicle for the spread of resis- tance genes. More than ﬁve different types of antibiotic resistance–carrying integrons have now been described. They differ among themselves by different amino acid sequences of their integrase enzymes. Hundreds of different integron-borne resistance gene cassettes have been identiﬁed. They differ by carrying different resistance genes against many different antibi- otics, and also by differences in the nucleotide sequence of the 59be. The different cassettes do not seem to have a speciﬁcity for a particular integrase. They carry a mobile genetic repertoire, the units of which efﬁciently move from inte- gron to integron and then contribute intensively to the spread of resistance genes. Antibacterial agents, antibiotics, have been distributed in the biosphere for about 70 years. From an evolutionary point of view, this is a very short period of time, and the degree of homology between the ﬁve integrases is roughly 40 to 60%, suggesting that their evolutionary divergence extends much longer. A similar structure must have been available in the microbial world for a long time, which later, under the selection pressure of antibiotics, developed into the resistance-spreading genetic vehicle we see today. These short sequences are very similar to 59be, described as a cassette component of the resistance-mediating integrons. One case is a resistance cassette carrying trimethoprim resistance (dfr6), and another is that of a betalactam resistance cassette carrying the gene carb4. It could be surmised to be an old structure evolutionarily, which by being able to exchange genes, has given its host a valuable adapt- ability upon the advent of drastic changes in the environment. In the case of the cholera bacillus, it is known that it survives bound to plankton in the sea, and then appears at times as a pathogen in epidemics. Most of the cassette-borne genes in the superintegrons studied are unknown and have no counterparts in available databases. In the case of the epidemiologically well-known Vibrio cholerae strain El Tor, the superintegron found carries an array of 179 cassettes, occupying about 3% of the total genome. In a similar fashion, the antibiotic resistance integron mediates adaptability and survival following the drastic environ- mental changes that the distribution of antibiotics has created. Speculatively, resistance integrons could have emerged from superintegrons by genetic recombinations under the selection pressure of antibiotics, by the entrapment of integrase genes and their corresponding attI sites by mobile genetic structures such as transposons. Thus by use of plasmid replicons, recombination mechanisms, and gene transfer mechanisms, bacteria can use the enormous pool of antibiotic resistance genes that are accessible when needed. No microbiologist can refrain from marveling at the ability of microbes to resist our best efforts to control or eliminate them. They have inhabited the world and adapted to many hostile environments for almost 4 billion years, so we cannot believe that we can conquer them within some seven decades of remedial effort. Pathogenic bacteria growing in human tis- sues have many different receptors for selective antibiotic action. Medicines that act pharmacologically, on the other hand, inter- fere with unchangeable physiological receptors in the tissue cells of humans and animals. For bacteria the presence of antibiotics involves a dramatic change in the environment, and the great ability of bacteria to adapt to changes in the environment (e. This rate of growth is reﬂected in very short generation times, which in the test tube can be measured in minutes and in human tissues in hours. Available antibi- otics are in many cases related to each other in terms of mechanisms of action on bacteria and then encounter similar mechanisms of resistance in bacteria. Antibiotics can be seen as appearing in families within which cross resistance is com- mon. In lists of antibacterial agents used for medical purposes in Western industrialized countries, there are ususally about 60 of these agents, antibiotics for systemic use. Roughly 50 of these can be included in ﬁve families, within which cross resistance occurs. The largest of these families is that of the beta- lactams, comprising about 30 members, including penicillins, cefalosporins, and monobactams. Cross resistance within this group is caused by resistance-mediating betalactamases, which can often hydrolyze the betalactam ring of many members of the betalactam group to inctivate their antibacterial action, and as described in Chapter 4, the betalactamases can change muta- tionally to adapt to different betalactams under the selection pressure of newly introduced betalactam derivatives (extended spectrum betalactamases). Other antibiotics families are tetracy- clines usually with about four members; aminoglycosides with some four members; quinolones with perhaps ﬁve members; and macrolides, including lincosamides and streptogramins, com- prising almost 10 members. A good example is the integron mechanism, described in Chapter 10, where evolution, under the selection pressure of antibiotics, has been able to adapt an ancient gene transport mechanism into a very efﬁcient tool for the dissemination of antibiotic resistance genes among bacteria. With an anthropomorphic perspective, medicinal chemists trying to produce new antibacterial agents can look at the bacterial world as a very old and wise antagonist. The development and evolution of antibiotic resistance can be looked upon as a modern and very rapidly unfolding example of the principles of Charles Darwin described in The Origin of Species. The organisms against which antibiotics direct their action grow very fast and are subjected to spontaneous muta- tions. By the mechanisms of horizontal movement of genes and of recombination, they also have access to a wide variety of genes from a very large group of environmental microorganisms. All these mechanisms and properties, at a low frequency, give rise to single resistant organisms, which then possess an acute sur- vival ability in the environmental niche formed by the presence of antibacterial agents, and will be selected to grow. This standard is threatened by resistance devel- opment, which is certainly very slow, but will in the long run interfere severely with the possibility of treating bacterial infections. Examples of acute situations in which all available antibiotics have been without effect because of resistance have been described internationally. The ﬁrst is simply to try to curtail the use of antibi- otics by using them more speciﬁcally via strict bacterial diagnosis and resistance determinations. The intension here is to lower the selection pressure, to at least slow down the development of resistance. The second principle is to investigate the origin of resistance and its dissemination in order to ﬁnd ways to neutral- ize its effects. The third principle includes making an inventory of antibacterial agents that have been left on the shelf by the pharma- ceutical industry, possibly because of a certain level of observed toxicity. In the end we might have to chose between the possibility of treating serious infections and the risk of side effects from the use of antibiotics. The fourth and most important basic principle for mastering antibiotic resistance is to try to ﬁnd genuinely new antibacterial agents. The pharmaceutical industry has shown a diminishing interest in this area for several years, however, at least regarding the continuation of the old tradition of screening for natural products.
And rapid cheap 2.5 ml xalatan otc medications side effects, shallow breathing has a way of increasing anxiety — not a useful cycle discount xalatan 2.5 ml with amex medications on backorder. Try this quick generic xalatan 2.5 ml overnight delivery medicine lake, easy-to-learn breathing technique to restore a calming pattern of breathing best xalatan 2.5 ml medicine qid. Slowly let your breath out through your lips while making a slight sound — hissing, sighing, or whatever. Talking with a Friend Anxiety is a lonely feeling, and loneliness increases anxiety. Research shows that social support helps people deal with almost any type of emotional distress. You may think that no one would want to hear about your troubles, but we’re not talking about whining and complaining. Adrenaline, a chemical produced by your body, causes your heart to beat faster, your muscles to tighten, and various other body sensations that feel distressing. Good examples include jogging; a long, fast walk; dancing; rope jumping; and tennis. Soothing the Body The most distressing aspect of anxiety is the way that it makes your body feel — tense, queasy, racy, and tight. Quick ways to temporarily break through the tension include the following: ✓ Soaking in a hot bath for a good while. Of course, if your budget allows for a longer massage performed by a professional masseuse, that’s great too! Chapter 21: Ten Ways to Stop Anxiety Quickly 307 Challenging Your Anxious Thinking The way you think strongly influences the way you feel. Anxious people inevita- bly think about things in ways that increase their anxiety. One of the best ways of dealing with anxiety is to examine the evidence for your anxious thoughts. Afterwards, ask yourself some questions about those thoughts, such as ✓ Is this worry truly as awful as I’m thinking it is? After answering these questions, try to write down a more realistic perspec- tive. See Chapter 5 for discovering more about how to write out your anxious thoughts, analyze them for distortions, and replace them with more realistic, calmer thoughts. But until you discover better ways of dealing with it, sometimes distractions can help. On the other hand, some anxious people get anxious about their sexual perfor- mance. If that’s you, don’t try this strategy — at least until you overcome your anxiety about this issue. And, if you don’t have an available, willing partner, we don’t recommend hiring one. And if it does occur, it rarely ends up being as catastrophic as the worriers predict. If you accept feeling just a bit anxious, the feelings abate more quickly than if you tell yourself that you must get rid of them at once. Chapter 22 Ten Ways to Deal with Relapse In This Chapter ▶ Realizing that anxiety happens ▶ Understanding the process of change ▶ Getting a booster shot f you’re reading this chapter, you’ve probably made some headway with Iyour anxiety. Maybe, after all your hard work, you’ve experienced a set- back, or perhaps you’re worried about one. Expecting Anxiety Perhaps you’ve worked hard to overcome your anxiety, and now your hard work has paid off. Counting the Swallows The proverb “One swallow doesn’t make a summer” reflects the fact that a single sign doesn’t necessarily indicate that something more is inevitable. You figured out how to handle some of your anxiety, and that knowledge can still help you. Thinking of minor setbacks as catastrophes will only increase your anxiety and immobilize your efforts. Checking Out Why Anxiety Returned Minor relapses are a great opportunity to discover what gives you trouble. Figure out what events preceded your latest bout of anxiety: ✓ Have you had some recent difficulties at work, such as deadlines, pro- motions, problems with co-workers, or financial setbacks? If so, understand that an increase in your anxiety is a natural response and likely to be temporary. Use the new information about your anxiety triggers to challenge your anxious thinking, as we describe in Chapters 5 and 7. Seeing a Doctor If you’ve looked high and low for situations or events that may have set off your relapse and can’t come up with anything at all, consider making an appointment with your primary care physician. Anxiety can have a number of physical causes, such as side effects from prescription medication or over- the-counter medications and supplements, excessive caffeine, and physical problems (see Chapter 3). If you experience anxiety with absolutely no apparent cause, please get a complete physical checkup. Revisiting What Worked Before If anxiety creeps back into your life, review the strategies that worked for you previously. Anxiety isn’t a disease that you can cure with a one-time injection, pill, or sur- gery. When it mushrooms to a distressing degree, you merely need to reapply your strategies for managing it. Chapter 22: Ten Ways to Deal with Relapse 311 Doing Something Different We’ve presented a variety of strategies for overcoming anxiety. Take a look at the list that follows, and choose one you haven’t gotten around to trying yet: ✓ Rethinking your anxiety (see Chapters 5, 6, and 7) ✓ Facing fear head-on (see Chapter 8) ✓ Engaging in relaxation strategies (see Chapter 11) ✓ Exercising (see Chapter 10) If you’ve simply dabbled at one or more of these techniques, pursue it more aggressively and see whether it works better that way. Most city newspapers list support groups for just about everything: various health concerns, emotional problems, relational problems, and, of course, anxiety. Millions of people suffer from anxiety, and they have great advice and support to offer you. Considering Booster Sessions If you’ve seen a professional and later experience an unexpected increase in your anxiety, think about calling for a few booster sessions. In addition, some people like to check in every few weeks or months as a kind of prevention. On the other hand, if you’ve never seen a professional and you experience a relapse, you should consider it now. If you’ve had previous success on your own, you’re likely to improve rapidly with a little assistance. Looking at the Stages of Change Any kind of change involves a series of steps or stages. As we discuss in greater detail in Chapter 2, these stages include ✓ Pre-contemplation: Not even thinking about change. For example, you may move back from action to contemplation or even pre-contemplation. Stepping back for a while doesn’t mean that you can’t gather the resources to make another run at the problem. Accepting Anxiety With this tip, we come full circle — back to the top of the list: Anxiety hap- pens. We’re not suggesting that you need to feel horrendous amounts of anxiety, but a little anxiety is unavoidable. And anxiety, when not overwhelming, may help mobilize your resources during difficult challenges. Chapter 23 Ten Signs That You Need Professional Help In This Chapter ▶ Contemplating suicide ▶ Slogging through work troubles ▶ Saying “No” to excessive drug and alcohol use ome people find that self-help is all they need.